Focal central neurological disorder in patients with autoimmune thyroid disease without encephalopathy.

The report underscores the necessity for a comprehensive evaluation in patients with suggestive laboratory findings or AITD history. Prompt diagnosis and appropriate management are imperative in averting long-term complications.

Risk of myocardial infarction in Parkinson's disease: A systematic review and meta-analysis.

BACKGROUND AND PURPOSE: Previous studies investigating cardiovascular disorders in patients with Parkinson's disease (PD) showed heterogeneous results regarding whether there is a higher or lower risk of myocardial infarction (MI) in these patients compared to the general population. Because of the inconsistency in findings, herein the aim was to perform a systematic review and meta-analysis to investigate the risk of MI in patients with PD. METHODS: A comprehensive literature search was performed using four databases, PubMed, Web of Science, Scopus and Embase, in June 2022. Peer-reviewed observational studies comprising case-controls, cohort, cross-sectional and longitudinal studies that reported MI in the PD population were included. RESULTS: After the screening, 20 studies with a total of 80,441 patients with PD and 802,857 controls were included in our qualitative and quantitative synthesis. The pooled estimated odds ratio for MI in PD patients compared to controls was 0.80 (95% confidence interval [CI] 0.56-1.05) which indicates that there is no association. The pooled prevalence of MI was 5% (95% CI 3%-7%) with a range of 1%-20% amongst patients with PD. The men (6%, 95% CI 1%-13%) and women (6%, 95% CI 1%-14%, Q = 29.27, I2 = 98.50%, p < 0.001) had similar MI prevalence. CONCLUSION: This comprehensive systematic review and meta-analysis provide compelling evidence that PD is associated with a reduced risk of MI. Whilst the exact mechanism underlying this association remains to be fully elucidated, it is clear that certain risk factors for cardiac events appear to be less present in PD patients, which may serve as a protective factor. However, given the reports of increased risk for cerebrovascular events in PD patients, it is possible that the major risk factors for MI and cardiovascular accidents in this population differ. These findings have important implications for clinical management and further research in this area is warranted.

Epidemiologic and histopathological evaluation of unclassified gingival papules in Urmia, Iran.

Objectives: Unclassified gingival papules might be mistaken with other malignant lesions as they resemble some other oral lesions. The present study demonstrates epidemiologic and histopathological characteristics of the gingival unclassified papules in the patients referred to Urmia Dental School, Iran. Materials and Methods: A cross sectional descriptive study design was conducted among 500 pateints in Urmai university of medical sciences, Iran. The participant's demographic data and medical history were obtained using clinical examinations and a questionnaire. Histopathological assessments were done in two specimens. The effect of the possible factors on the incidence of gingival papules was statistically assessed by Fisher's exact test. Results: Among 500 participants, 340 (68%) demonstrated unclassified gingival papules (40.9% males, 59.1% females; mean age of 34.9 years). No significant differences were found regarding the effect of gender, smoking, mouth breathing, history of skin disease or pregnancy on the incidence of gingival papules. However, the breastfeeding females (P < 0.004) or those using contraceptive pills (P < 0.02) showed lower frequency of papules' incidence. Among 340 papules, 332 (97.6%) were white in color, 337 (99.1%) were well defined and 331 (97.3%) were observed in the keratinized gingiva. 207 (60.9%) were multiple and 133 (39.1%) were single lesions. The papules showed healthy tissues similar to gingival tissue; however, abundant collagen bundles were irregular and close to the surface, which was covering by stratified squamous epithelium. Conclusion: Gingival papules are common findings in patients referring to Urmia Dental School; the lesions were almost white in color, well defined and appeared in the keratinized gingiva. The lesions were a variation of normal oral structures with no treatment requirements.

Healthier living with MS: The key role of self-efficacy and emotion regulation.

OBJECTIVES: Understanding distress and quality of life (QOL) is important in improving the lives of people with multiple sclerosis (MS), and investigating their antecedents is very important. The present study aimed to examine the role of multiple sclerosis self-efficacy and difficulties in emotion regulation in predicting distress and QOL in people with MS. Also, this study compared types of MS (RRMS, PPMS, and SPMS) in terms of MS self-efficacy, difficulties in emotion regulation, distress, and QOL. METHODS: This study included 122 people with three types of MS (RRMS=33, PPMS=62, and SPMS=25). Data were collected by the use of four scales: Quality of Life (QOL), Psychological Distress (DASS), Difficulties in Emotion Regulation (DERS), and Multiple Sclerosis Self-Efficacy (MSSE). Pearson's correlation, path analysis, MANOVA, and Tukey's post hoc test were used for data analysis. RESULTS: Findings indicated MS self-efficacy had negative and significant effects on difficulties in emotion regulation and distress and had a positive and significant effect on QOL. Difficulties in emotion regulation had a negative and significant effect on QOL and a positive and significant effect on distress. Also, the indirect effect (through difficulties in emotion regulation) of MS self-efficacy on distress and QOL was significant. In addition, the comparisons showed that differences between RRMS and SPMS in terms of MS self-efficacy and distress were significant. CONCLUSIONS: Self-efficacy and emotion regulation are key components in improving the life (reducing distress and increasing QOL) of people with MS, although it depends to some extent on the type of MS disease.

Immune checkpoint inhibition for the treatment of cancers: An update and critical review of ongoing clinical trials.

Advances in Cancer immunotherapy in the past few years include the development of medications that modulate immune checkpoint proteins. Cytotoxic T-lymphocyte antigen 4 (CTLA4), programmed cell death protein 1 (PD1), and programmed cell death ligand 1 (PD-L1) are three co-inhibitory receptors that are expressed in the tumor microenvironment. Immune checkpoint inhibitors (ICI) that target these biomarkers unleash the properties of effector T cells that are licensed to kill cancer cells. Immune checkpoint blockade has dramatically changed the treatment landscape of many cancers. In this Review, we describe the current data regarding clinical trials of ICIs in six important cancers, including hepatocellular carcinoma (HCC), renal cell cancer (RCC), hodgkin lymphoma (HL), non-hodgkin lymphoma (NHL), non-small cell lung cancer (NSCLC), and head and neck cancer carcinoma (HNSCC).

Efficacy of multi-walled carbon nanotubes in regulating growth performance, total glutathione and redox state of Calendula officinalis L. cultivated on Pb and Cd polluted soil.

Multi-walled carbon nanotubes (MWCNTs) have recently attracted huge attention to their impacts on the environment and plants. Therefore, this experiment was conducted to investigate the responses of lead (Pb) and cadmium (Cd) exposed pot marigold plants to various levels of MWCNT. Calendula officinalis (L.) seedlings were cultivated in Pb and Cd-polluted soils with exposure to 0, 50, 100, 250, 500 and 1000 mg L-1 of MWCNT. The results demonstrated that foliar-applied MWCNT up to 250 mg L-1 not only alleviated Pb and Cd-induced toxicity by reducing oxidative damage and boosting both enzymatic and non-enzymatic antioxidant defense system but also promoted the phytoremediation property of pot marigold plants by enhancing the accumulation of both Pb and Cd from the soil. Interestingly, oxidative damage exacerbation and both Pb and Cd accumulation reduction were noticed in pot marigold seedlings exposed to 500 and 1000 mg L-1 MWCNTs. The findings of this study clearly showed that the use of appropriate concentrations of MWCNTs in increasing the phytoremediation properties of pot marigold was justified, while the use of high concentrations is toxic to the plant and intensifies the toxic effects of heavy metals (HMs) on plant physiology. This study provides a novel method to facilitate the phytoremediation of HMs polluted soils using MWCNT as well as explores the potential risks of these nanoparticles to the plants.